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When Niomi was 13, her mother, a primary school teacher, developed cancer and the teenager had to care for her younger siblings.
After two years it had all got too much for the youngster and she moved into a hostel.
Aaliyah - killed in a plane crash last year - took the best video title for More Than A Woman, while TLC member Lopes, killed in a car crash this year, was given an outstanding achievement award.
During her lifetime, Lopes scored seven top 20 hits in the UK with her band, featured on Mel C's number one Never Be The Same Again and had a solo hit.
It got to the point where I didn't go out anywhere. 'I'd wake up in the morning, have a smoke, go to school, come back, have a drink - to the point of, like, I'm coming to the end, I can't take it any more.
Friends say the split was 'amicable' but it exacerbated the money problems which were already plaguing the family.Richard Henley, her form tutor for six years, described her as a 'great kid'.He added: 'She is the type that you knew would do well and succeed in whatever she did.Acclaimed US act Norah Jones - whose father is Indian sitarist Ravi Shankar - took the best jazz act prize.Soul diva Chaka Khan, who scored hits fronting the band Rufus before going solo and having a UK number one with Prince's I Feel For You, took the lifetime achievement award.Bandmate Heidi Range was not to be outdone as she showed off her midriff with a pair of black hipster trousers. The full list of winners is as follows::: Best R'n'B act - Ashanti.:: Best video - Aaliyah.:: Best hip-hop act - Ja Rule.:: Best reggae act - Sean Paul.:: Best garage act - Mis-Teeq.:: Best gospel act - Michelle Williams.:: Best jazz act - Norah Jones.:: Best world music act - Angelique Kidjo.:: Best producer - Neptunes.:: UK act of the year - Ms Dynamite.:: Master Card best album- Songs In A Minor, Alicia Keys.:: Best single - It Takes More, Ms Dynamite.:: Best newcomer - Ms Dynamite.:: Best UK DJ - Steve Sutherland.:: MOBO unsung award - Street Politiks.:: MOBO lifetime achievement award - Chaka Khan.:: MOBO contribution to urban music - Jimmy Cliff.:: MOBO outstanding achievement award - Lisa "Left Eye" Lopes.Other stars who trooped in past the crowds included Craig David who was due to air his new single What's Your Flava? You don't need to have a big bum and breasts - I ain't got none of that.It's what's in your mind."Many of the top prizes were grabbed by overseas acts but Britain's haul included a best garage prize for Mis-Teeq, whose singer Alesha Dixon was hosting the awards alongside US rapper LL Cool J.After seeing off such competition as David Bowie and the bookmakers' favourites The Streets, the garage and rap star blurted out: 'I really don't know what to say. Oh my goodness.' Behind the award of the £20,000 prize on Tuesday night is an astonishing tale of triumph over adversity.Niomi was born on a tough estate in Archway, North London, to a Jamaican father and Scottish mother.